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It functions as a metabolic modulator by inhibiting the NNMT enzyme, rather than acting as a signaling peptide

Management should focus on eliminating repeated exposure and reducing inflammation, often with topical or oral steroids when appropriate. A dermatologist can prescribe those medications

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EGF is bioactive but barrier-limited: the molecule does what it does only if it reaches the keratinocyte layer, and standard topical formulations deposit most of it on the stratum corneum where it has no relevant receptor

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