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Ozempic (semaglutide) activates GLP-1 receptors in the gastrointestinal tract, which has raised questions about its effects on irritable bowel syndrome

In the STEP 1 trial extension, participants who discontinued semaglutide regained two-thirds of their prior weight loss within one year

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Serious side effects are rare when medications are prescribed and monitored properly through a licensed provider, and GLP-1 compounds have an established safety profile from millions of doses worldwide

Bibcode:1956Sci...124..484C

Studies on callus growth and morphogenesis in several species and lines of Amaranthus