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P = 0.01

Studies comparing DPP-IV inhibitors with GLP-1 receptor (GLP-1R) agonists have shown greater weight loss and reduction in glucose excursions in individuals treated with GLP-1R agonists [20]

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Patients carrying specific GLP1R variants often experience enhanced appetite suppression at lower doses, while others may require higher titration to achieve equivalent appetite control

Aging Renal or hepatic impairment (and other pre-existing medical conditions) Alcohol use Concurrent use of certain medications Malnutrition Note : Always read dosing instructions and warnings on every medication

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