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Clinical studies showing significant wrinkle reduction typically measured results at the 8-week mark

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doi: 10.1016/S0076-6879(78)52032-6 4 ChenF.WangF.WuF.MaoW.ZhangG.ZhouM

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Specifically, it upregulates genes involved in collagen synthesis (Types I, III, and V), decorin production (which regulates collagen fibril assembly), integrin and glycosaminoglycan synthesis, DNA repair enzymes, antioxidant defense systems (superoxide dismutase, glutathione), and stem cell markers