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Among them, the most common AE of olpasiran was injection site reaction (primarily pain)

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That suggests the amylin and GLP-1 pathways create a synergistic interaction, not just a combined one

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Published steady-state exposure puts 14 mg oral daily closer to a 0.5 mg weekly injection, and even 25 mg oral daily lands near a 0.9 mg weekly injection short of Wegovy 2.4 mg. Switching routes is an exposure change, not a brand swap