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Caspase-1 cleaves gasdermin D (GSDMD), whose N-terminal fragment forms pores in the plasma membrane, leading to cell lysis and the release of proinflammatory cytokines such as interleukin 1 beta (IL1B), IL-18, and IL1A [70]
Furthermore, in genetically sensitive people, environmental factors including UV radiation, oxidative stress, and infections may cause the production of TNF-, which can lead to the development or aggravation of vitiligo 42
The low level in serum/plasma was associated with vitiligo incidence, at whatever active stage or stable stage, especially in segmental vitiligo
A single overnight temperature excursion (812 hours at 2025C) typically causes 815% degradation depending on ambient temperature and light exposure