The accumulation of altered key tumor suppressor genes such as TP53 and CDKN2A, which encode p53 and p16INK4A, respectively is associated with the onset, progression and poor prognosis of HPV-negative HNSCC
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secondary antioxidants are known to be scavengers of ROS, and tertiary antioxidants repair the oxidized molecules through sources like dietary or consecutive antioxidants
Healthy cells are crucial for a strong immune response, as they efficiently detect and combat pathogens
Foods with glutathione + selenium include Brazil nuts, eggs, sunflower seeds, and fatty fish like tuna and sardines
Ethanol metabolism, CYP2E1 induction, compromised antioxidant defenses, mitochondrial injury, activation of Kupffer and stellate cells, hypoxia, and iron overload can all contribute to the alcohol-induced oxidative environment