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First, glycaemic control improves rapidly after surgery, enabling discontinuation of insulin and other glucose-lowering medications, even before substantial weight loss has occurred

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A post hoc analysis of the phase IIb trial showed that tirzepatide was associated with a reduction in the level of high-sensitivity ICAM-1, CRP, and YKL-40 after 26 weeks of treatment in a dose-dependent manner [83, 103]

Understanding these pathways helps contextualize potential benefits and guides realistic expectations

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