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This in turn implies that the first of the two phases for which the thiolate-FAD charge transfer diminishes for the U597C enzyme, with an approximate rate constant of 2 s 1 , occurs as a result of the C154 C159 thiol/thiolate pair reducing the C596-C597 disulfide

10.1021/tx060142s 39 KonK.KimJ.-S.JaeschkeH.LemastersJ

The overlap in claimed benefitsparticularly glucose controlcreates natural concern about safety

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This staged approach minimises gastrointestinal side effects but means the full therapeutic effect is not immediate

Importantly, stem cells play a repairing role by migrating to the injured sites, inducing directional differentiation, eliciting paracrine effect and modulating the immune response