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This is the dose that produced the 24.2% body weight reduction in Phase 2 trials

The longer the participants took these drugs and the higher the dose, the more severe these effects

It is typically characterized by early onset (in childhood and adolescence), more pronounced weight gain, higher body fat percentage, and more severe hyperphagia, often accompanied by endocrine disorders (such as hypogonadism)

Ntika S, Thombare K, Aryapoor M, Kristinsson H, Bergsten P, Krizhanovskii C

Later innovations like tirzepatide expanded on this by targeting two receptors (GLP-1 and GIP) to improve metabolic function

This compensated state can persist for years in some individuals