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It has therefore been a major interest to develop profiles for personalized medicine or treatment strategies including biomarkers for risk stratifications, which could end in a scenario where treatments are targeted to the patients that have the highest likelihood of responding

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However, these trials concentrated on cardiovascular outcomes rather than ocular ones, with inconsistent definitions and grading, rendering them insufficient for evaluating the long-term stabilization or enhancement of retinal pathology following an acute reduction in glycosylated hemoglobin (HbA1c)

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The enzyme prohormone convertase (encoded by the PCSK1 gene) then cleaves proglucagon into several active peptides, including GLP-1