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When considering trial data, composite kidney outcomes were considered to give a better overall measure of long-term kidney protection than any single kidney endpoint (91%)

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Since oxidative stress and inflammatory biomarkers are objective results that are less susceptible to detection bias than subjective clinical endpoints, this is a significant strength of the evidence foundation

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Although interventions such as carnosine (Abraham et al., 2021), folinic acid (Frye et al., 2018

Finally, the combination allows for investigation of both GHRH and ghrelin pathway interactions, providing richer data for growth hormone axis research