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Oxyhemoglobin suffers autoxidation daily (23%), with oxidation of heme ferrous iron into ferric iron [10], leading to the formation of methemoglobin (metHb), which is not capable of O 2 transport, and the release of superoxide anion that is converted to H 2 O 2 , with a lower oxidant capacity [11]

Lemasters et al., showed that hair follicles have specific compartments of mitochondrial gradients and oxidative metabolism, which leads to increased ROS during the development of the hair shaft that they termed a ring of fire 94

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doi: 10.1038/s42255-023-00966-w 75 NrregaardPKDeryabinaMATofteng SheltonPFogJUDaugaardJRErikssonPOet al