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Tirzepatide combines GLP-1 with GIP (glucose-dependent insulinotropic polypeptide)

In my experience reviewing the clinical data, the glucose-lowering effect of retatrutide is strong enough that many people on insulin need their dose reduced within the first few weeks

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Additionally, there is evidence suggesting that GLP-1 sensitivity could link salt sensitivity to insulin resistance

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Eng personally secured a patent and partnered with Amylin, leading to the FDA-approved diabetes drug exenatide in 2005, the first GLP-1 analog