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The dose is increased stepwise according to your response and tolerance: Weeks 58: 0.5 mg weekly Weeks 912: 1.0 mg weekly Weeks 1316: 1.7 mg weekly Week 17 onwards: 2.4 mg weekly (maintenance dose) Your doctor will tailor this schedule to your unique medical history and progress

Expect that major volume changes require medical or nutritional interventions

Lower nausea rates, fewer dropouts, identical weight loss results

Nat Chem Biol 22 , 10871098 (2026)

Gastrointestinal adverse events were not collected as predefined outcomes unless they resulted in documented treatment discontinuation

Some patients report that eating a light meal shortly after injection feels more comfortable than fasting, since food may reduce stomach acid exposure and settled digestion feels less disrupted