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The mechanism likely involves the medications effects on gastrointestinal motility and secretion patterns

Patients should pause further dose increases until symptoms have settled and discussed with their healthcare team

Glutathione is known to influence the production of melanin, the pigment that gives skin its color

Wang L, Volkow ND, Berger NA, Davis PB, Kaelber DC, Xu R

Some research has examined the relative merits of pulsatile GH release (as produced by injectable GHS peptides) versus continuous GH elevation, with pulsatile patterns generally considered more physiologically favorable for maintaining receptor sensitivity

Those findings do not directly apply to the lower-dose transdermal estradiol plus micronized progesterone regimens that contemporary guidelines, including the Menopause Society's 2022 position statement, consider lower-risk for appropriate candidates