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What the potency comparisons actually showed In the classic anabolic studies, IGF analogs with reduced IGFBP binding including Long R3 IGF-1 produced greater nitrogen retention, greater gut and organ growth, and more pronounced anabolic responses than equimolar native IGF-1 in rodents, particularly in catabolic states such as dexamethasone treatment or dietary restriction

Older people usually produce less stomach acid and therefore less intrinsic factor, increasing their risk for deficiency

Joshua Kritzer, an associate professor of chemistry at Tufts University, says the study offers evidence that the stapled peptide approach is worth pursuing and could lead to new drugs that interfere with specific protein interactions

[DOI] [PMC free article] [PubMed] [Google Scholar] Hegde M

In addition, IF enhances lysosomal activity, which improves the degradation and recycling of cellular waste