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Tirzepatide shows superior outcomes (21-22% weight loss) compared to semaglutide (13-17% weight loss) in head-to-head trials

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, cytosolic versus mitochondrial pools), and the surrounding metabolic and enzymatic environment

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Developers now have access to multiple half-life extension technologies, each generating its own patentable structural territory: Fc fusion: Fusing a therapeutic protein to the Fc region of an IgG antibody recruits the neonatal Fc receptor (FcRn) recycling pathway, extending half-life to weeks