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Multiclonal expansion and high prevalence of -lactamase-negative Haemophilus influenzae with high-level ampicillin resistance in Japan and susceptibility to quinolones

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The dose escalation period represents the most challenging phase, and strategic timing of supportive peptides can ease this transition

elegans DAF-16: dauer form 16 (FoxO ortholog in the worm) FoxO: forkhead box transcription factor class O GH: growth hormone GHR: growth hormone receptor G.I.: glycemic index GIP: glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide) I.I.: insulinemic index IIS: insulin/IGF-1 signaling IGF-1: insulin-like growth factor-1 IGF1R: insulin-like growth factor-1 receptor IR: insulin receptor IRS: insulin receptor substrate PI3K: phosphoinositide-3 kinase Leu: leucine mTORC1: mammalian target of rapamycin complex 1 ROS: reactive oxygen species S6K1: S6 kinase 1 T2D: type 2 diabetes Trp: tryptophan

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and the long breeding cycle, particularly when pyramiding multiple resistance genes or combining resistance with high agronomic performance