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Since its introduction in the 1980s, endocrine therapy with tamoxifen has been the first-line treatment for breast cancer in estrogen-receptor-positive men and women

[145] [150] [151] The most important transcription factors [note 12] that produce these alterations are Delta FBJ murine osteosarcoma viral oncogene homolog B (FosB), cAMP response element binding protein (CREB), and nuclear factor-kappa B (NF-B)

Patients who struggled at 5mg often tolerate 7.5mg better than expected because their GI system has had eight weeks to adjust

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Coverage questions are worth raising directly during intake