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Statistics showed that PC1/3 and PC2 in Model group was significantly lower than that in Control group, and then increased after berberine treatment (Figures 4C, D)

(1992, Biochem J) demonstrated that IGF-1 and its variants including Long R3 IGF-1 are anabolic in dexamethasone-treated rats, confirming the utility of IGF-1 LR3 in models of catabolic states and muscle wasting where native IGF-1 activity is suppressed by glucocorticoid-driven IGFBP upregulation

However, a small percentage of patients discontinue treatment specifically due to persistent or severe gastrointestinal side effects

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Human IAPP (hIAPP) is the major component of the amyloid deposits found in the pancreatic islets of patients with T2DM