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This helps reduce caloric intake so patients can lose weight

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13 14 Beyond lowering fat accumulation in the liver, GLP-1s also improve liver-driven heart risk by decreasing inflammation and reducing levels of enzymes that release artery-damaging particles

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TRIUMPH-4 is the first pivotal trial to confirm that the weight-loss signal seen in Phase 2 scales with longer exposure and higher doses, and it adds several new secondary findings that reshape how researchers think about 9 mg and 12 mg as working doses

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You should contact your GP if natural approaches to improving metabolic health have not yielded results after 3-6 months, if you have been diagnosed with type 2 diabetes or non-diabetic hyperglycaemia (pre-diabetes, HbA1c 42-47 mmol/mol), if you are struggling with obesity-related health complications, or if you experience unexplained weight changes, persistent fatigue, or excessive thirst and urination

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Oral GLP-1 Drugs Could Be the Next Market Disruption Oral GLP-1 drugs may become the most important access story in obesity treatment

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