Am J Clin Nutr 63(5):797S-811S
Deficiency of vitamin B12 can lead to abnormal neurologic and psychiatric symptoms including ataxia (shaky movements and unsteady gait), muscle weakness, spasticity, incontinence, hypotension, vision problems, dementia, psychoses, and mood disturbances BENEFITS OF B12: More energy, mental alertness and stamina for everyday tasks Healthier immune systems Improves sleep Increases metabolism, thereby aiding in weight loss Reduces allergies, stress and depression Improves mood stabilization Lessens frequency and severity of migraines and headaches Helps lower homocysteine levels in the blood, thereby reducing the probability of heart diseases and strokes POSSIBLE SIDE EFFECTS AND CONTRADICTIONS OF B12: A vitamin B12 shot is safe and generally has no side effects, even in higher doses
Inadequate B12 levels can lead to impaired red blood cell formation, resulting in megaloblastic anemia, a condition characterized by fatigue and weakness
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Given the poorly characterized specificity of enzymes involved in thiamine transformation and the often unknown roles of genomics-identified isoenzymes, all human isoenzymes are included in Figure 3 when there is evidence that at least one isoenzyme can catalyze the reactions with thiamine or its derivatives
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