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Washington (DC): National Academies Press (US)

Author contributions ER: Writing original draft, Writing review and editing

Opioid-induced hyperalgesia (OIH) In the long-term management of opioid analgesic therapy, opioid-induced hyperalgesia (OIH) is a paradoxical opioid effect and should not be forgotten: OIH often leads to the need to reduce or modify the therapy (41)

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