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Find articles by Santoro, N
Medications such as Semaglutide and Tirzepatide mimic this hormones activity, signaling the brain to reduce hunger and slow gastric emptying, leading to improved portion control and sustained weight loss
All studies used balanced populations (inverse probability of treatment weighting or propensity score matching) and accounted for informative censoring (inverse probability of censoring weighting)
For GLP-1, the review confirmed insulinotropic effects on -cells during hyperglycaemia, glucagonostatic effects on -cells during hyperglycaemia (indirect, via somatostatin and insulin), gastric emptying delay, CNS appetite suppression, and indirect promotion of lipolysis via increased sympathetic activity
There are not enough data to determine the impact of GLP-1 medicines on human pregnancies but, in some animal studies, GLP-1 medicines were found to be harmful to the unborn foetus 34
