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Histopathological analysis and immunohistochemical staining revealed decreased expression of K16, K17, and Ki67 in SFN-treated mice, indicating reduced abnormal differentiation of keratinocytes and cutaneous inflammation

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Additionally, melatonin upregulates mixed-lineage kinase domain-like pseudo kinase (MLKL), a downstream protein in the necroptosis pathway [165, 169]

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