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We are working on the hybrid synthesis, where we make some [peptide] pieces with SPPS and then we will couple [them] together with an enzyme. So far they have done this for liraglutide using a unique ligation point the site where the enzyme couples two natural amino acids

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The parent complex has a molecular weight near 403404 g/mol, and the acetate-salt form near 462 g/mol

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PMID: 32162820