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Although many enzymes in one-carbon metabolism are affected by the sex hormones testosterone and estradiol, the main reasons for sexual dimorphism in glutathione metabolism are the effects of estradiol and the GSH regulatory motif, which includes the inhibition of GS and GCL by GSH itself [Figure 2B]

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The review noted that in animal models, BPC-157 was associated with reduced levels of pro-inflammatory cytokines signaling molecules involved in tissue inflammation

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This allows researchers to test a range of doses on a smaller cohort, identifying the minimum effective dose and any potential adverse effects before committing to a larger, more resource-intensive study