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If patients experience severe gastrointestinal symptoms or dehydration, stopping GLP-1 therapy temporarily is advisable

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Expect possible out-of-pocket costs These medications can be costly, so planning is important

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Our research group has been involved in the development of chalcone derivatives as potential selective COX-2 inhibitors for the past few decades (127, 128), (76, 77, 87, 129-132)