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Nrf2 Activation as a Strategy for COVID-19 Treatment The involvement of Nrf2 signalling in coronavirus disease 19 (COVID-19) is sustained by the marked cytoprotective ability of Nrf-2 in responding to stressors and its potential role in the treatment of pathologies characterized by oxidative and/or inflammatory events

Frontiers in Pharmacology , 12, 654125

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This risk is heightened by genetic variants such as the OATP1B1 R57Q polymorphism, which impairs drug transport and can lead to systemic toxicity (62, 63)

The available animal studies were not sufficient to resolve this concern because they did not provide a comprehensive dose-ranging, long-term carcinogenicity programme

In circulation, the bioavailability of native IGF-1 is tightly regulated by a family of six IGF binding proteins (IGFBP-1 through IGFBP-6), which sequester ~99% of plasma IGF-1 and limit its receptor-accessible fraction