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There's not a lot of 400 pound 70 year old men so I don't see many

Diarrhea on tirzepatide can cause dehydration and electrolyte imbalances that promote water retention

Journal of Nutritional Biochemistry, 67(2), 75-82

Like with all medications it is possible that a very small number of patients may experience very severe side effects

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Chest 141(2 Suppl):e44Se88S Witt DM, Clark NP, Kaatz S, Schnurr T, Ansell JE (2016) Guidance for the practical management of warfarin therapy in the treatment of venous thromboembolism