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2.2 Study population The study population consisted of patients with overweight or obesity who were prescribed either tirzepatide or other anti-obesity medications, including bupropion, naltrexone, orlistat, topiramate, phentermine, or setmelanotide

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However, the gut microbiome's influence on GLP-1 secretion is complexwhile certain bacterial metabolites like butyrate may support intestinal health, directly stimulating GLP-1 production through probiotics alone has not been validated in large-scale human trials