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Coexistence of diabetes and hypertension has been found to increase fibrosis burden in comparison to having either diabetes or hypertension alone (van Hoeven and Factor, 1990)

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4 Therefore, the use of a GLP-1 receptor agonist (exenatide, liraglutide) can be used as monotherapy or dual therapy in those with an A1C of 6.5% to 7.5%

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HFpEF is characterized by the presence of different comorbidities such as type-2 diabetes mellitus (T2DM), visceral obesity and ageing, all contributing to systemic metabolic inflammation [7, 8]

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