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Metabolic Significance ERRs are master regulators of cellular energy metabolism, controlling the expression of genes involved in fatty acid oxidation, oxidative phosphorylation, the citric acid cycle, and mitochondrial biogenesis

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This approach would capitalize both on our understanding of circadian pathophysiological pathways in asthma, and existing redox-targeted therapeutics, whilst minimizing off-target effects associated with hormone based therapies such as melatonin