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(2013) reported results from a randomized, placebo-controlled clinical study evaluating oral AOD9604 in overweight subjects

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No hGH Receptor Binding or IGF-1 Stimulation AOD9604 did not induce hyperglycaemia or reduce insulin secretion in sharp contrast to chronic intact hGH treatment and confirmed that the concept of hGH behaving as a pro-hormone is valid, with fragments capable of acting via mechanisms novel to traditional GH receptor-stimulated pathways

Many also fail to document their process thoroughly, making it difficult to troubleshoot or reproduce results