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If you have normal GI function and no malabsorption issues, oral supplementation can provide adequate methyl donors but youll need higher doses (5001,000mcg B12 daily, 12g methionine daily) to match injection bioavailability

Neurosci Lett 722:134854 Cenini G, Lloret A, Cascella R (2019) Oxidative stress in neurodegenerative diseases: from a mitochondrial point of view

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However, you should always pick the form thats best for your personal needs and goals