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Further, AC facilitates nitric oxide (NO) production through regulation of inducible nitric oxide synthase (iNOS) to ameliorate the inflammatory response (Seo et al

NAD+'s metabolic roles encompass several key pathways: Energy production : NAD+ regulates glycolysis, the citric acid (TCA) cycle, oxidative phosphorylation, and fatty acid oxidation by functioning as a cofactor for redox reactions Redox balance : The NAD+/NADH ratio controls flux through metabolic pathways, ensuring properly regulated cellular metabolism Mitochondrial function : NAD+ is essential for ATP synthesis through oxidative phosphorylation, where NADH donates electrons to complex I in the electron transport chain Biosynthetic processes : Through its phosphorylated form NADP+, it supports anabolic reactions and cellular antioxidant defense mechanisms NAD+ directly shapes cellular processes that maintain tissue homeostasis

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No negative interaction [24]

The committee recommends that DoD, in cooperation with others, continue to develop better clinical biomarkers of TBI (i.e., concussion/mild, moderate, severe, penetrating, repetitive, and blast injuries) for the purposes of diagnosis, treatment, and outcome assessment