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(14) Because all trial data informing this analysis were obtained from relatively short-term trials, we performed a scenario analysis in which the efficacy of each medication on all outcomes decreased by 5% per year from 2020 to 2040

22 Liu, H.-L

A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis

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Like I feel like you're also saying here that there is a lot of power in the kind of anecdotal things