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Interestingly, after discontinuing Pycnogenol and placebo intake in the fifth cycle of the study, subjects of the Pycnogenol group reported a continuation of the trend, as their need for analgesics was even more reduced (50% compared to baseline), while women of the placebo group experienced a rapid return to analgesics

For example, antioxidant gene therapy has been suggested as a means of overcoming the problem of poor delivery and bioavailability of antioxidant compounds at their intended sites of action (Firuzi et al., 2011)

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Ischemic acute kidney injury induces a distant organ functional and genomic response distinguishable from bilateral nephrectomy