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Transcript McCall McPhereson: [00:00:00] These medications originally were meant to treat diabetes two decades ago

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For instance, vitamin b1 is nerve energizer, vitamin b6 helps in nerve signal transmission, while as vitamin b12 work as nerve generator

Mandrika and colleagues (Biochem Pharmacol, 2001, PMID 11239505) examined melanocortin peptides on NF-B DNA binding in RAW 264.7 macrophage-like cells and reported evidence for dual mechanisms of action, and Kannengiesser and colleagues (Inflamm Bowel Dis, 2008, PMID 18092346) reported effects in murine colitis models that were partly independent of MC1R

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Mechanisms, clinical trial results, side effect profiles, dosing protocols, regulatory status, and practical considerations for anyone trying to understand which compound might better align with their goals