Subgroup analyses were performed for TPV and stenosis to assess potential effect modification of: baseline plaque levels (higher or lower than median), average weekly red meat consumption (higher or lower than median), sex (male or female), and study site
Clinically significant portal hypertension events were defined as the first occurrence of esophageal varices (i.e., with and without bleeding), gastric varices, ascites, hepatic failure, hepatorenal syndrome, portal hypertension, liver transplant status, fibrosis and cirrhosis of liver, hepatic encephalopathy, jaundice, and chronic passive congestion of liver
Insulin resistance can also affect the balance of other hormones, such as leptin and ghrelin, which regulate appetite and satiety
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When stimulated excessively, these cells can grow abnormally