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But once these patients weight lowers and their metabolic and cardiovascular health improves, there is no protocol for finding a maintenance dose for them

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Mechanisms of Action: From Obesity to Addiction GLP-1 agonists enhance insulin secretion, slow gastric emptying, and promote satiety by acting on GLP-1 receptors in the hypothalamus and other brain regions involved in hunger regulation

Receptor binding activates Gs/cAMP/PKA signaling, with downstream activation of GH gene transcription and exocytosis of pre-formed growth hormone from secretory granules [2]