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Long-acting agonists include liraglutide, exenatide(Bydureon), albiglutide, dulaglutide, semaglutide, PEG-loxenatide and tirzepatide, which can maintain an appropriate agonist level in plasma throughout the 24 hours of the day

Intermediate values were observed for liraglutide (11 days, IQR 257), tirzepatide (19 days, IQR 369), lixisenatide (20 days, IQR 5116), and semaglutide (27 days, IQR 577) (Table S6)

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The 540 nm data are also consistent with initial rapid equilibrium binding in that the initial value at the time equivalent to the instrument deadtime increases and appears to saturate with increasing NADPH concentration