J Med Chem (2015) 58:737080
NAION: Diagnosis and Management
Briefly, FFAs can reduce the tyrosine phosphorylation of insulin receptor substrate-1 by activating the serine/threonine kinase, thereby aggravating IR (151)
Journal of the American College of Cardiology Advances
Precision is also paramount in terms of getting optimal treatment for people, and the appeal of different treatments might differ amongst people. GLP-1 Treatments Face Hurdles While GLP-1s offer promising benefits for some patients, significant barriers remain regarding supply, cost, and insurance coveragechallenges that Saunders describes as humongous limitations. Novo Nordisks Ozempic and Wegovy have been on the FDAs drug shortage list since 2022
This makes dietary and behavioural strategies especially meaningful for individuals with impaired GLP-1 signalling, such as those with insulin resistance, obesity or type 2 diabetes