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The CB1 receptor mediates the peripheral effects of ghrelin on AMPK activity but not on growth hormone release

Contact your GP or healthcare professional promptly if you experience: Persistent vomiting (unable to keep down fluids for more than 24 hours) Severe or prolonged diarrhoea (lasting more than 48 hours) Signs of dehydration : excessive thirst, dark urine, dizziness, reduced urine output Muscle weakness or cramps (particularly if severe or persistent) Irregular heartbeat or palpitations Unusual fatigue or lethargy Severe persistent abdominal pain, especially if radiating to the back (may suggest pancreatitis) Seek urgent medical attention (call 999 or attend A&E) if you develop: Severe chest pain or pressure Difficulty breathing or shortness of breath Severe muscle weakness affecting mobility Confusion or altered consciousness Fainting or collapse These symptoms may indicate significant electrolyte disturbances or other serious complications requiring immediate assessment

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Gebre-Medhin, S

These references, and those cited elsewhere in the specification, are hereby incorporated by reference in their entirety

Conclusions The findings illustrate that GLP-1RAs are associated with a lower risk of various hematologic cancers, especially MDS and MPN, in T2D patients