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While most current medications target one or two hormones, Retatrutide is a triple-agonist meaning it works on three metabolic pathways at once: GLP-1: curbs appetite and helps you eat less GIP: supports nutrient utilization and lean muscle metabolism Glucagon: boosts fat burning and overall energy expenditure In short, it doesnt just help you eat less it helps your body burn more and keep muscle while losing fat

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Rats that receive a single subcutaneous dose of glucagon exhibit a sharp rise in metabolic rate, which is consistent with this theory [36]