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The major trials treated GLP-1s as long term, chronic therapies, with benefits maintained only while the medication was continued

Constipation is a common side effect of Ozempic and other GLP-1 medications, such as Wegovy and Rybelsus

(2010) 21 Suppl 7:vii3205

Both classes of agents reduce cardiometabolic risk factors such as HbA1c, body weight, blood pressure and albuminuria, although the effects of GLP-1 receptor agonists on glycemia and body weight are substantially greater than those of SGLT2 inhibitors

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