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Chronological (Intrinsic) Aging Intrinsic or chronological aging is a natural process with the passage of time that causes inflammation with the production of reactive oxygen species (ROS) resulting in oxidative stress from cellular metabolism, which results in a loss of skin homeostasis [9, 10, 14] (Fig

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their metabolic byproducts (postbiotics), particularly SCFAs like butyrate, are potent immunomodulators (241)

The effects of glutathione deficiency are far-reaching and may include: Increased oxidative stress and inflammation Impaired immune function Neurodegenerative disorders, such as Parkinsons disease and Alzheimers disease Increased risk of cancer and other chronic diseases Poor wound healing and tissue repair Increased susceptibility to infections Understanding the importance of maintaining adequate glutathione levels is crucial for preventing these adverse health effects and promoting overall wellness