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Examined in studies in relation to gut-related processes

Nat Rev Dis Primers 1 , 15080 (2015)

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Conclusions Intensive lifestyle modification remains the cornerstone of MASLD management

Effect of short-term high calorie and/or high-fat diet in inducing insulin resistance The literature consistently reports that short-term HC, HC with high-fat (HCHF) or HFD impair insulin action as measured by glucose tolerance tests, mixed meal challenges or hyperinsulinemiceuglycemic clamp (Table 2), confirming that high-fat and/or HC diets are a suitable model to study diet-induced insulin resistance

334-OR: pemvidutide (ALT-801), a balanced (1: 1) GLP-1/glucagon dual receptor agonist, induces rapid and marked weight loss without the need for dose titration in people with overweight/obesity