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It may even cause problems in people with MTHFR, polymorphisms, or other pretty common genetic polymorphisms

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[DOI] [PubMed] [Google Scholar] Cirillo C, Sarnelli G, Esposito G, Turco F, Steardo L, Cuomo R (2011) S100B protein in the gut: the evidence for enteroglial-sustained intestinal inflammation

The rationale is borrowed from other compounds where tissue saturation and receptor dynamics justify phased dosing

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Research in Cell Death & Disease reveals that the glutathione system is essential for protecting cardiovascular tissue from oxidative injury